Are jenny mcCarthy and Melissa mcCarthy related?

it could be likely but probably not because McCarthy is a common last name

NO

well my name is Jessica McCarthy and no i am not related to him his name isn't McCarthy so probably not!

McCarthy began dating actor/director John Mallory Asher in 1998 and as engaged to him in January 1999, was married to him by September of the same year. The couple had an autistic son named Evan...

For the whole list got to Wikipedia.org and find her filmography. Under that should be a whole list of tv shows she's been on.