Not advised. Only if you wanna blow your thumb off,get blind,or mess up your gun....The .22 LR's case is smaller in diameter,so when you pull the trigger the case is going to swell instantly to fit...
Some revolvers are capable of firing both cartridges, simply by replacing the cylinder. Not all revolvers can do this, however. As for a dedicated .22LR firearm not fed from a cylinder, the answer is...