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No they are not related
No it is a coincidence that they have the same last name.
Barry Sanders has a fan mail adress...Adress:Barry Sanders The Access Goup, Inc. 846 Lincon Road5th Floor Miami Beach, FL 33139-2618 USA
Barry was always listed right around 200 lbs. I have seen his weight as high as 203, but the majority of the time he was listed at 200 lbs. He was also 5'8".