It appears there is not an obvious interaction, but its STRONGLY recommended you work with your provider.
see following article by a doctor familiar with this:
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SAM-e should be fine with an antidepressant. It is going to interact with other hormone medications. Lexapro will be OK to take. Remember to take your Lexapro every day even if you don't feel you...
From my expirience yes but not in high doses(like over 100ml daily).It may cause serotonin effect.Also the best would be to skip lexapro that day if you not going to take tramadol on daily basis.
I have been taking wellbutrin (bupropion) for about 4 years now, and my doctor just added sertraline (zoloft) to take as well. He told me that the two are perfectly fine to be taken together. And...