Can a werewolf be genetically created by splicing human and wolf DNA?

Answer 1

No.

*New Author improving Answer*

You cannot make a werewolf in the traditional sense which is basically a polymorphic creature and the human body can not generate enough flesh, blood, bone, sinew, etc to be able to handle that kind of metamorphosis.

However, theoretically it is possible to introduce foreign DNA, like that of a wolf for example, into a human. You need to first isolate the gene (here's the first problem, since the Human Genome Project only just finished mapping OUR DNA) then using chemicals, cut away the specific gene sequence and insert it into an length of human DNA in the proper spot. This DNA can be replicated with relative ease, and then placed in a viral vector (a virus not harmful to humans) that will literally infect the existing cells with the new DNA code.

But what good would it do? Everything in the body works of of responses to proteins, and we wouldn't be able to tell if that protein sequence did anything for a while, or if our organs are capable of carrying out that specific coding and interacting with existing cells to create new organs.