There do not appear to be any long-term side effects from chymotrypsin therapy if precautions for its use are followed.
high-dosage intravenous injections of alkaloids isolated from fritillaria produced pupil dilation, tremor, slowing of the heart rate, and lowered blood pressure in human subjects.
One source reports that the side effects of gastrodia include skin allergies, hair loss, and other allergic reactions.
Some subjects have reported side effects such as headache, stiff neck, drowsiness, cognitive distortion or confusion, dizziness , and anxiety.
At very high dosages, boron may cause nausea and vomiting, diarrhea, and headaches.