It depends. If they are multiple voltage 110-220v appliances (such as most computer power supplies are) they obviously can be, taking special care to check if a switch has to be flipped to use the...
Because a 220 volt appliance will draw 1/2 the current of a comparable 110 volt appliance. This means you can run smaller wire than for a comparable 110 volt appliance. 220 volt appliances are...