it will if you use compatibility mode
duchess.
Type on your keyboard: "Dmstuff" to get all the weapons and inventory items. And Type: "Dmhollycorn" For god mode. That's all I know for Duke Nukem 3D. Duke Nukem Rocks!
You only need to buy Xbox live if you want to play online.
There are several online stores to buy keys. Have a look at Related Links below.