Common symptoms include headaches , vomiting, gait disturbances, and ataxia , especially when the cerebellum is involved.
Mutations in the VHL gene on chromosome 3 are now known to cause the condition. VHL is inherited in an autosomal dominant manner.
The condition affects people of all ethnic groups worldwide, with an equal proportion of males and females.
There is no cure for von Hippel-Lindau disease. Treatment and management are often based on symptoms.
VHL often involves symptoms in the central nervous system (CNS) and include hemangioblastomas of the cerebellum , spinal cord, brain stem, and nerve root.