Can you mix NyQuil and antibiotics?

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Yes. These are two separate classes of medication that do not interact with each other, nor do they have similar effects that could amplify. In fact, Nyquil, being something you take for colds and flus, is formulated to be taken alongside other medications the cold/flu sufferer may take.
While it's always a good idea to check with your doc or pharmacist, I'd say you're safe on this as long as you follow the dosing instructions properly.
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