Not really, wheat germ has a different flavor and texture than white wheat flour. If only a small amount is called for some whole wheat flour may work.
Wheat germ is going to be a very small part of any recipe, it is there more as a nutritional supplement. Depending on the recipe, it may add slightly to the overall flavor, but for the most part, it...
I have successfully substituted ground flax meal for wheat germ in some baking recipes with great success. I thought the flavour and texture was much better.