Although some in vitro data indicate synergism between macrolide antibiotics and penicillins, other in vitro data indicate antagonism. When these drugs are given together, neither has predictable...
according to Epocrates.com, there appears to be no significant drug interactions
There is always a possibility of drug interaction...you should call your pharmacist!
I have no problem with reflux esophagitis , but Nyquil gives me heartburn anyway, so I'd say no.