Can you take acetaminophen and tramadol together?

Yes. They are two different compounds that work well together.

So well that some formulations of tramadol contain acetaminophen already, going under the brand name Ultracet. So make sure you read the label before you add more acetaminphen/Tylenol (or even take Nyquil). If you see tramadol + APAP, this means you have that generic formulation. Acetaminophen can do severe liver damage (to the point of killing you). It has a daily limit of 4000mg. 3000mg if you are going to be using it every day.

Tramadol is a special kind of opiate, where it works both like morphine and also on serotonin receptions. Therefore, there IS a daily limit, and it can potentially interact with SSRI/SNRI medications, as well as the tripan migraine medications (which also work on serotonin receptors). Supplements such as St. John's Wort work on serotonin receptors as well. It is important to make sure your prescribing physician knows everything you are taking and to follow the prescribing advice on how much to take.