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Yes. They are safe to take together though may cause marked drowsiness. Be sure to only take as directed.

Benadryl, or Diphenhydramine Hydrochloride, is the "active" ingredient in sleeping aids like "Tylenol PM". As drugs go, it's one of the safer ones, and is not subject to abuse.

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13y ago
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14y ago

Yes, but the side effects tend toward general fatigue or sleepiness and can sometimes result in a headache. Avoid operation of heavy machinery after taking one or more doses of those medications.

It is rare, but this combination can also cause hyperactivity and irritability as well as an increase in heart rate.

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13y ago

I wouldn't recommend this; benadryl is an antihistamine with the side effect that it can make you sleepy, and hydrocodone, the active ingredient in Vicodin, can also cause drowsiness.

Benadryl, or Diphenhydramine Hydrochloride, is the "active" ingredient in sleeping aids like "Tylenol PM". As drugs go, it's one of the safer ones, and is not subject to abuse.

But mixing two medications that both cause drowsiness may not be safe. Discuss this with your pharmacist.

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11y ago

Benadryl can sometimes be taken alongside cough syrup containg codeine. However, both medications can cause drowsiness so it would be advisable to seek further advice from a health professional before proceeding.

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15y ago

I have been prescribed codeine and benadryl simultaneously. It may slightly reduce the effectiveness of the codeine, but that's all.

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Q: Can you mix Benadryl and Tylenol with codeine?
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