Hydrocodone is normally dispensed tied with another drug, such as acetominophen or ibuprophen. If your hydrocodone prescription is labeled APAP or Lortab, it is tied to acetominophen. If it is...
There is no direct interaction listed between Benadryl (diphenhydramine) and LorTab (Hydrocodone and acetaminophen).
Note however that many OTC meds containing diphenhydramine also contain...
Benadryl is taken to suppress allergies, however Prednisone suppresses the immune system, and therefore your allergies as well. If you are on Prednisone, taking Benadryl is pointless because...