Yes, but you will be more sedated than usual. The first time you try this, do it in the morning when you' not sleeping. Then, once you know how you react, you can proceed accordingly.
There is no direct interaction listed between Benadryl (diphenhydramine) and LorTab (Hydrocodone and acetaminophen).
Note however that many OTC meds containing diphenhydramine also contain...
You can check all know interactions of drugs yourself with the website http://www.drugs.com/drug_interactions.php. Simply type in the drugs you wish to find and select the correct drug from the...