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It's best to avoid the decongestants pseudoephedrine and phenylephrine, especially in the first 13 weeks of pregnancy, since there have been some reports of birth defects. Although the risk appears to be low, it could be higher if you're a smoker. After 13 weeks, occasional use of these medications - for example, once or twice daily for no more than a day or two - is probably safe. More frequent use, however, can reduce blood flow to the placenta.

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Q: Can you take phenylephrine while pregnant?
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