I don't know how safe it is, but I have been taking Xanax, Seroquel and Cymbalta (or Effexor XR before the Cymbalta) for about 1 1/2 years now. I take them together at night to sleep and it works well.
Yes, My Doctor gave me Zoloft daily to treat panic attacks and Xanax to spot check any additional panic episodes. Nothing bad should happen other than being very tired.
I'm not really sure my doc gave me the zoloft for anxiety and Xanax for panic attacks and the amitriptlyne for sleep. I took it once and next day thought I was on my death bed! So my recommend NO!
It wouldn't be a good idea to mix all of those, but I've mixed a lot of stuff myself. soma's with ambien and xanax and klonopin and hydrocodone and Oxycontin. (no kidding) but it isn't wise to mix...