Yes you can, try spacing them out by at least 10 hours because the benzoyl peroxide ingredient is known to tamper with tazoratene (aka tazorac). If evenly, spaced throughout the day, both can be used in conjunction and yield superior results than either medication alone. This study http://findarticles.com/p/articles/mi_m0PDG/is_3_5/ai_n16120894/pg_3/?tag=content;col1 confirms this fact.