on day-PEE duh (meaning "in spite of" or "despite") -- you don't actually pronounce the "n" in on, it's a nasal sound, and the "o" is sounded in the back of the throat, not the up front way of the...
Okay, the Istmo de Panama is like a large beach located to the right of the Small Country, Panama. Panama is the very end of the strip of land and islands that connects the Americas.