About 300 miles.
432.34 kilometres (268.65 miles)
1. Head east on Main St toward S St Paul St 0.4 mi 2. Take the ramp to US-75 S 0.2 mi 3. Keep left at the fork to continue toward US-75 S and merge onto US-75 S 0.7 mi 4. Continue on I-45...
453.51 kilometres (281.8 miles)