The driving distance from Frankfurt am Main to Heidelberg is approximately 50 miles (80 km) travelling along the A5 Autobahn.
Google maps are helpful. About 90 km, takes about an hour by car on the Autobahn.
Not far. Two hours tops if you are driving. The drive is nice because you go through little villages and it is very pretty. By train less than an hour. Again this is a guess because I never timed the...
205.37 miles (330.52 kilometres)
341 miles / 549 km