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Some, but most of the times it will be members of the team selected randomly, unless the league has reasons to believe a certain player may have taken something to boost his performances. In a lot of leagues, a refusal to take a drug test will result in a permanent ban.
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Why do pro sports teams make players take urine drug tests?
Professional sports team force players to take urine drug tests to avoid cheating by using performance enhancing drugs. Steroid use is a common problem among pro athletes in competitive sports.
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