Do you believe there is one or more slot machines in any given casino that are set in the players favor and if so why?

Yes and No. As the saying goes 'the house always wins'. Many slot machines in casinos have a set payout rate; usually in the ranges of about 90-98% (the highest payout rates are in Las Vegas). The 2% that doesn't pay out goes to the casino, they make huge amounts of money from slot machines, even at the highest payout rates.

In terms of them being in players favor many gamblers who have made a living from casinos have always stated that the best chances to make gains are with the slots rather than using a system with roulette or Blackjack. The payouts with the slot machines are on average a lot more than the table games.

When you look at games like Roulette you have a 48% chance of winning on a European Roulette table and 47% chance of winning on the American Table. Compared to a 90-98% payout rate on the slots you can see why a lot of people say the slots are in the players favor.