This is from a Farside cartoon by Gary Larson. Patrick Henry was the American revolutionary who is famously quoted as saying "Give me liberty, or give me death!" In the cartoon, Patrick Henry is...
The significance is in the words themselves. When Patrick Henry uttered those words he had a noose around his neck and he was telling his tormentors that he would rather die a free American than live...
Give me liberty or give me death was a famous quote Patrick Henry said it means to give us freedom or give us death meaning make us die because the colonist were so upset they didn't want to live