Has any college basketball team that was ranked 64th ever upset the Number One ranked team in the NCAA tournament?

Answer

No. No 16 seed has ever beaten a 1 seed in the opening round.

Answer

16 seeded Harvard defeated 1 seed Stanford in the 1998 women's NCAA tournament. That is the only victory by a 16 seed in either the men's or women's tournament.

Answer

Like the second guy said and there was one by steve nash's college team, and a team on a game no one ever saw but was in si in like 1940

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