Your first cousin's granddaughter is your first cousin, twice removed.
Your second cousin's granddaughter is your second cousin, twice removed.
Your third cousin's granddaughter is your third cousin, twice removed.
It gets more complicated, and there are more possibilities, if you are asking about the granddaughter of a first cousin once removed, of a second cousin once removed, of a first cousin twice removed, etc.
My sister's daughter (the FIRST "little girl" in the question) would be my Niece, therefore making me her Aunt.
Once my Niece had a daughter (the SECOND "little girl" in the question) she would be my Great Niece making me her Great Aunt. Now, if the Great Niece had a daughter, she would become my Great Great Niece and THEN I would be the Great Great Aunt.
You are the Great Aunt.
You are your sister's grandson's great aunt (if you are a woman) or great uncle (if you are a man.
Your sister's grandson is your great nephew.
your second cousin
Grandaughter
You would be second cousins.
grandaughter in-law
grandaughter
Your daughter and your sister's child are first cousins. Your daughter and your sister's grandchild are first cousins, once removed.
Your child and your sister's child share a common grandparent and are first cousins. Your grandchild and your sister's grandchild share a common great grandparent and are second cousins. There is a generation out of synch, so they would be second cousins once removed.
sisters are people who are related
Your granddaughter and your niece's son (the grandson of one of your siblings) are second cousins to each other.
They are related to you by marriage.
Danielle Riley is Lisa Marie's Daughter with her first husband,Danny Keough. She is Elvis's grandaughter.
Your grandaughter would call your brother her great uncle.
No, they are not related. They played twin sisters in the movie "Double Teamed".