Random multiple cylinder misfire, is when the engine cylinders do not fire in the correct order, and do not do it constantly. There is no particular pattern to it. My experience with this condition...
You locate the cause of the random misfire and take corrective actions against that; be it a coil, plug, wire, coil boot or crank sensor.
A random misfire is as it states - a misfire that happens...
My P0300 code has been determined to be caused by low compression in 2 cylinders: due to burnt valves.
I had this same problem. I ended up having a new cat put on along with an engine modual...
Make sure you check the EGR valve, mine went bad and it gave me a multiple cylinder misfire code...
It means it is misfiring on more than one cylinder. A new set of plugs and or plug wires may fix...
1st check the spark plug, make sure the electrode didn't brake off and it is clean and properly gapped, next check the plug wire make sure it's not broken or arcing out. If the wire appears ok change...