Yes, You can. It works fine with windows 7, You just need to change the compability to Windows XP, You can to that by right-clicking on the exe file and click on the compability tab.
Um , as far as I can tell , Medieval II: Total War Only operates on Windows 2000/XPHere are the full system Requirements. www.gamespot.com/pc/strategy/medieval2totalwar/tech_info.html