There are tests to check for chlamydia and gonorrhea in a urine test. Sometimes, one can also see the protozoa of trichomoniasis in urine as well, but this is not a specific test, only an observation.
P - larger projectile than a 9 or 357 or 38. Many fine semi-autos made for it..
C - ammo can be hard to find worldwide. Recoil depending on size of pistol
It's pretty universal isn't it? I don't think we could live for long without it. It powers all sorts of useful things, and some we could do without, but you would surely have to be very eccentric to...