the west produced raw materials which were sold to the east, who had major industry. they eventually turned the raw materials into finished products and sold them back to the west. So the biggest...
The land and plantations that people were in. The frontier moved westward so did those people/immigrants. The relocation and redefinition of the frontier moved westward over a period of time...same...
It eventually led to the Civil War. When slaveowners wanted to migrate west, they wanted to take their slaves with them but it became a politicial issue whether the state/territories would allow...