That depends entirely on what you wish to cancel.
i loved what about brian in the first season, but then in the 2nd season, they jumped over all the cliffhangers.......and fast forwarded into fall. not to mention the lack of keeping characters on...
it wasnt getting enough support, like viewers, ratings, ect.
The only way to cancel a loan is to pay it off. The lender owns the loan and you have no control over it at all.