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How do thiazide diuretics cause hypercalcemia?

In: Health, Medication and Drugs [Edit categories]

Answer:

In the kidney, the DCT reabsorbs about 8% of the filtered Ca2+ load. This occurs via epithelial Ca2+ channels. In the steady state, the cell must extrude all entered Ca2+, which occurs via a Ca2+ ATPase, and also through Na+/Ca2+ exchanger located on the BASOLATERAL surface of the cells of the distal tubule. Thiazides inhibit the Na+/Cl- symport in the early DCT, thus causing a decrease in INTRAcellular Na. This, in turn, enhances the activity of the Na+/Ca2+ exchanger, creating an increased driving for Ca 2+ resorption through the epithelial Ca2+ chnnels. The final effect: increased Ca2+ reabsorption that can cause hypercalcemia or more often, unmask hypercalcemia due to other causes. ie; maligancy

First answer by ID0417807821. Last edit by ID0417807821. Question popularity: 1 [recommend question].

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