How do you know that a cow has mad cow?

Answer:
She will be acting quite aggressive towards any "strange" movement. She will be very nervous, have no habituation if something startles her repeatedly, and very unsteady on her feet. Soon she will go down, go into a coma, and die.

A dead cow, if cut open to reveal the brain, will exhibit a characteristic degeneration of brain tissue confirming bovine spongiform encephalopathy, or "mad cow disease."
Contributor: Wildrosebeef
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