Answer:
Let's split this word in several parts to be able to pronounce it :
"oeu" is one sound, it is like the U in English in "but"
"v" is the same sound than in English
"r" is the standard French R, it doesn't exist in English, it is like a Spanish J in which you add voice
"e" you don't always need to pronounce it, it depends on the sound in the phrase that will follow "oeuvre" : if it is a vowel the "e" in "oeuvre" isn't pronounced, if it is a consonant, the "e" in "oeuvre" will be pronunced almost like the first sound "oeu" but with the mouth a little bit more closed, it is like the sound "ö" in German.