Answer:
There is an answer and this will make sense. Try this: "That that is, is. That that is not, is not. Is that it? It is!"
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There is no way the sentence can be punctuated because it doesn't make sense. In order to properly punctuate a sentence, there must be some element of common sense in the structure. This is just a random string of is that it.
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Rather than using one or more punctuation marks, I would prefer to use an editing mark and draw a line through the entire text indicating that it should be deleted in its entirety.
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