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How does a genomic library differ from a cDNA library?

In: Genetics, Libraries and Library History, Biochemistry [Edit categories]

Answer:

A cDNA (complementary DNA) library is a DNA library that has been created from mRNAs that are present in the cell. Since a cDNA is created from mRNA transcripts, that means that in Eukaryotic organisms there will be no introns or transcriptional factors present in the cDNA library, only exons. Only protein coding regions will be present in a cDNA library. This also means that a cDNA library is often times tissue specific. Since the expression of mRNAs will be different in different tissues of the organism it will appear different then a genomic library. Often times to offset this problem a cDNA library will be composed of different tissues (brain, liver, heart) to encompass a greater variety of the proteins that are expressed. A genomic library will contain all the exons, introns, and transcriptional factors that are not found in the cDNA library.

**2/24/2011**

cDNA library does contain exons, which is the protein coding regions.

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Anh

First answer by ID2197145792. Last edit by Wonges. Contributor trust: 0 [recommend contributor ]. Question popularity: 2 [recommend question].

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