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Tobacco may induce certain cytochrome P450 enzymes in the liver, thereby increasing the susceptibility of smokers to the potentially hepatotoxic effects of some drugs, including acetaminophen. It may also diminish the liver 's ability to detoxify dangerous substances, and it may affect the dose of medication required to treat a particular liver disease. Furthermore, it may worsen the course of alcoholic liver disease.

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Q: How does chewing tobacco effect liver disease?
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