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How does gene amplification cause drug resistance?

In: Health, Medication and Drugs, Genetics [Edit categories]

Answer:

When a drug is administered, it is given at a prescribed dose so the active ingredient can bind and inhibit a particular enzyme, or target. Gene amplificatin increases the amount of copies of a particular area of chromosome and thus increases the amount of mRNA which will be transcribed. If the target is amplified over and over, it reaches a point to where the drug is not binding to enough of the substrate to be effective. Essentially, gene amplification dilutes a normal dose and in order to combat it, higher dosages are needed.

First answer by ID2170376751. Last edit by ID2170376751. Question popularity: 1 [recommend question].

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