When systemic disease or distant metastasis occur, melanoma commonly involves the lung, brain, liver, or occasionally bone. The malignancy causes death when its uncontrolled growth compromises vital organ function.
It is estimated there will be 553,400 total cancer deaths in the United States in 2001. Malignant melanoma will account for 7,800 of these deaths, for an incidence of 1.5% of total deaths related to...
A number of rare mutations, which often run in families, are known to greatly increase one's susceptibility to melanoma. One class of mutations affects the gene CDKN2A[disambiguation needed]. An...