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How does zinc ion hydrolyze RNA?

In: Biochemistry [Edit categories]

Answer:

Zinc in its most common +2 oxidation state is actually a fairly good Lewis acid will not hydrolyze RNA since RNA is quite stable at low pH. Chelated with imidazole or carboxylates, however, zinc can achieve a pKa of around 7, allowing for general base hydrolysis of RNA. For this reason imidazole buffers are generally not used with RNA unless RNA cleavage is desired.

First answer by Seven Three. Last edit by Seven Three. Contributor trust: 5 [recommend contributor ]. Question popularity: 1 [recommend question].

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