110 miles taking this route: Take I-85 SOUTH from Atlanta to I-185 SOUTH to COLUMBUS off EXIT 21. Take I-185 SOUTH to Columbus.
206.61 kilometres (128.38 miles)
According to Google Maps, the driving distance varies between 40.2 and 44.0 miles. See link below for driving directions.
The distance from Columbus, GA to Atlanta, GA is about 107.6 miles if you take I-85 N. That's about a hour and 50 minute car drive.
It is 225.32 miles according to MapQuest.