Orion [See Link] is a constellation and thus has many stars of different distances from us. The nearest is GJ 3379 at around 17 light years. The brightest is Rigel at around 800 light years.
2,793.98 kilometres (1,736.11 miles)
114.71 kilometres (71.28 miles)
161.52 kilometres (100.36 miles)
1,694.11 kilometres (1,052.67 miles)