329 miles taking this route:
- Take I-69 SOUTH to I-465 SOUTH at EXIT 0 in northeastern Indianapolis.
- Take I-465 around Indianapolis to I-65 SOUTH to LOUISVILLE at EXIT 53B.
- Take I-65 SOUTH to I-265 WEST/SR-62 WEST TO I-64 to NEW ALBANY at EXIT 6B.
- Take I-265/SR-62 to I-64 WEST/SR-62 WEST to ST. LOUIS at EXIT 0 in New Albany.
- Take I-64 WEST to U.S. 231 SOUTH to DALE and OWENSBORO at EXIT 57A.
- Take U.S. 231 SOUTH to Owensboro.