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How is osteogenesis imperfecta caused?

Answer:
OI is a genetic disease. The inheritance pattern is usually autosomal dominant. This means an affected person will have OI even though only one faulty gene has been passed along. This faulty gene can come from either parent, and it can affect either sex. Each child of an affected parent will have a 50 percent chance of developing OI.

Occasionally, a person will develop OI even though neither parent carried the faulty gene. This is called a spontaneous mutation. A person who develops OI will have the same chance of passing it on to a child as does someone who inherited the autosomal dominant gene.

It is important for you to understand that nothing you or your spouse did during conception or pregnancy caused this condition in your child. OI has been prevalent for thousands of years. Genetic counseling, which is available at most hospitals, may help you understand.
First answer by Waqseua. Last edit by Waqseua. Contributor trust: 5 [recommend contributor recommended]. Question popularity: 3 [recommend question].