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The first effective polio vaccine was developed in 1952 by Jonas Salk at the University of Pittsburgh. The Salk vaccine, or inactivated poliovirus vaccine (IPV), is based on three wild, virulent reference strains, grown in a type of monkey kidney tissue culture which are then inactivated. An enhanced-potency IPV was licensed in the United States in November 1987, and is currently the vaccine of choice in the United States. In 2002 a combination vaccine (called Pediarix) containing IPV was approved for use in the United States. The vaccine also contains combined diphtheria, tetanus, and acellular pertussis vaccines (DTaP) and a pediatric dose of hepatitis B vaccine.

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Q: How is polio vaccine produced?
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