It can happen on the first dose; it can happen on the last dose, or anywhere in between.
If you experience itchiness and a rash, swelling of the face/tongue/lips, stop taking it immediately, contact your doctor and take Benadryl. If you are swelling enough that you are unable to breathe, your throat is closing in (or wheezing like asthma), or you feel faint - get to the ER/call an ambulance.