How long can you be on Wellbutrin before it stops working?

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Generally, medications don't stop working. Sometimes the situation changes, and the medication is no longer the best option for treatment, and sometimes something as simple as a higher dose is necessary. I don't know what you consider to be not working, or how long you've been on the medication. Many people take wellbutrin for long periods of time (several years or more). If you feel your dose of wellbutrin is no longer effective, talk to your prescriber. The maximum daily dose is 450mg, anything higher than that can significantly increase your risk of seizures and other adverse effects, and has not been shown to be any more effective than the normal therapeutic doses. Good luck!!

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