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Wellbutrin is metabolized to active metabolitrs. The half life of the parent drug is 21 hours and that of the active metabolites range from 20 hours to 37 hours depending on the metabolite. This means that it can take from 5 to 8 days for the drug to be eliminated from the body.

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15y ago
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14y ago

The serum half life for buproprion is 21 hours, or about one day. You should stop feeling it's effects in a few days. However, you should wait two weeks before starting any drugs which interact negatively with buproprion.

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13y ago

If you break it, probably 15 minutes, otherwise probably 30-60. It's a very subtle prescription; It varies between everyone I've met. Some people like me feels its benefits, others feel nothing.

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14y ago

Wellbutrin XL stays in the system for approximately 8 to 10 days.

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13y ago

Approximately 2 weeks per OB/GYN doctor.

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Q: How long does it take for bupropion to get in system?
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