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Benadryl, or diphenhydramine hydrochloride, when taken by mouth, works within 15 to 60 minutes. When injected through a muscle, it takes 20 to 30 minutes to work. When injected through a vein, it works rapidly. The effects of diphenhydramine hydrochloride work for approximately 4 to 8 hours, regardless of the form in which it is taken.

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13y ago
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11y ago

One does NOT give benadryl to cats or any other animal, this would be an insane thing to do, it is a cough medicine for adults only!!!!!!!!!!!!

To the smarty pants who wrote the above post.....you are wrong. It is perfectly fine to give a dog benadryl just look up the correct dosage by your dogs weight

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10y ago

It depends on the size of the dog. A small dog should be anywhere from 10 minutes to 30 minutes and a large dog should be around 30 minutes to an hour. It also depends on how much you give the dog.

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14y ago

For Allergies or itching, it takes about 45 minutes to an hour an a half.

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13y ago

Benadryl is anti tissue expectorant diphhydramine hydrocholoride cough syrup and is effect within 20-30 minutes of administration.It works for almost 6-8 hours.

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11y ago

15 to 60 minutes

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11y ago

It takes about 10 minutes or less.

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Q: How long does it take for benadryl to work on cats?
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